Cyclic hexapeptide oxytocin antagonists. Potency-, selectivity-, and solubility-enhancing modifications

J Med Chem. 1990 Jul;33(7):1843-5. doi: 10.1021/jm00169a001.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Arginine Vasopressin / metabolism
  • Cell Membrane / metabolism
  • Female
  • Indicators and Reagents
  • Kidney / metabolism
  • Liver / metabolism
  • Molecular Sequence Data
  • Molecular Structure
  • Oxytocin / antagonists & inhibitors*
  • Oxytocin / metabolism
  • Peptides, Cyclic / chemical synthesis*
  • Peptides, Cyclic / pharmacology
  • Rats
  • Receptors, Angiotensin / drug effects*
  • Receptors, Angiotensin / metabolism
  • Receptors, Oxytocin
  • Receptors, Vasopressin*
  • Solubility
  • Structure-Activity Relationship
  • Uterus / metabolism

Substances

  • Indicators and Reagents
  • Peptides, Cyclic
  • Receptors, Angiotensin
  • Receptors, Oxytocin
  • Receptors, Vasopressin
  • Arginine Vasopressin
  • Oxytocin